果冻影院

and colleagues are celebrating receipt of a 拢179,000 grant from Crohn鈥檚 & Colitis UK to investigate how cells communicate with each other during inflammation.

The award represents the charity鈥檚 first-ever clinical research fellowship and will allow PhD student Dr Greg Sebepos-Rogers to look at the role of proteins IL-1尾 and optineurin (OPTN).听

Dr Smith said: 鈥淗ow cells communicate with each other is crucial in our understanding of inflammatory bowel disease.听

鈥淚nvestigating how so-called 鈥榤essenger proteins鈥� IL-1尾 and OPTN interact inside the cell during inflammation could uncover new targets for biological drugs.鈥�

The study will also attempt to create organoids using cells taken from gut biopsies and blood samples from people with Crohn鈥檚 or Colitis.

These groups of cells will be grown together in the lab to create a 3D model of the gut which can be used to understand how gut and immune cells talk to each other under different conditions.听

Helen Terry, Director of Research at Crohn鈥檚 & Colitis UK said: 鈥淚t鈥檚 incredibly important that we attract the top talent into Crohn鈥檚 and Colitis research and Greg is an exemplar of the type of clinician we want to pursue IBD as a career.听

鈥淗e is passionate and intelligent and we are extremely proud that he will be badged a Crohn鈥檚 & Colitis UK Fellow.听

鈥淭he research he is undertaking could lead to new treatments for people with Crohn鈥檚 and Colitis and we are excited to follow his journey over the next two years and beyond.鈥�

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Pictured听(L-R): Dr Andrew Smith and听Dr Gregory Sebepos-Rogers