¹û¶³Ó°Ôº

There is a variety of research activity taking place at the Institute. Below is a list of research areas, each with details of project titles within that area suitable for study at MPhil/PhD level.

To discuss any potential MPhil/PhD further, please do not contact potential supervisors directly.ÌýAll enquiries should be directed to the Research Student AdministratorÌýatÌýedi-phd@ucl.ac.uk.

You can also browse PhD projects by supervisor.

Antibiotic resistance

Project titles:

New therapeutics for tuberculosis: identification and characterisation of cofactor biosynthesis pathways and their role during infection Supervisor:

Rational design of future drug combinations as a strategy to combat antibiotic resistance and superbugs Supervisor:

Exploring gene transfer in the whole oral microbiota metagenomics, oral microbiota, mobile genetic elements Supervisor:

Novel approaches to understanding how the important nosocomial pathogen Clostridium difficile causes disease Clostridium difficile, virulence, antimicrobial associated disease Supervisor:

Bacterial virulence

ÌýProject titles:

Identification of novel therapeutic targets in bacteria associated with healthcare infections such as staphylococcus aureus and 'superbugs' such as VRE and MRSA Staphylococcus aureus, MRSA, enterococci, VRE, virulence Supervisor:

Novel approaches to understanding how the important nosocomial pathogen Clostridium difficile causes disease Clostridium difficile, virulence, antimicrobial associated disease Supervisor:

Biofilms

Project titles:

Constant depth film fermentor models of gingivitis and periodontitis gingivitis, periodontitis, biofilms Supervisor:

Development of new strategies for treating implant infections biofilms, enterococci, periodontal pathogens, Staphylococcus aureus, Staphylococcus epidermidis Supervisor:

Molecular mechanisms of biofilm formation Staphylococcus aureus, MRSA, VRSA Supervisor:

Synthetic biology to develop agents for disrupting medically important biofilms molecular breeding, domain shuffling, enzymes Supervisor:

Understanding biofilm regulation in Campylobacter jejuni biofilms, signalling, virulence Supervisor:

Bacterial vitamin biosynthesis pathways and their role in the homeostasis of the oral microbiomeÌý Supervisor: Ìý

Biomaterials and composites for matrix tissue engineering

Project titles:

Catalyst free synthesis of polyesters for tissue engineering Neurogenic and Osteogenic peptide delivery via polymer matrices Development of Degradable Fibres for Hard and Soft Tissue Engineering Silk fibroin and degradable polyurethane composites with improved mechanical properties Supervisor:

Large-scale synthesis of a novel microbial-derived polymer Development of a biomimetic membrane for wound dressing Long-term cell storage and delivery Supervisor:

Caries Microbiology

ÌýProject titles:

Novel signal transduction mechanisms in Streptococcus mutans Ìý³§³Ü±è±ð°ù±¹¾±²õ´Ç°ù:

Synthetic biology to develop dental plaque disrupting agents molecular breeding, domain shuffling, enzymes Supervisor:

Development of novel antimicrobial therapies

Project titles:

A synthetic biology approach to the development of phage therapy to bacterial diseases phage, oral acquisition microflora, caries Supervisor: /Ìý

Identification of novel therapeutic targets in bacteria associated with healthcare infections such as staphylococcus aureus and 'superbugs' such as VRE and MRSA Staphylococcus aureus, MRSA, enterococcus, VRE, virulence Supervisor:

Development of novel antimicrobial agents and identification of antimicrobial agents produced by microorganisms novel antimicrobials, metagenomics, antimicrobial peptides, bacteriocins Supervisor:

Metagenomics for natural product discovery Supervisor:

Biofilm disruption activities in natural environments Supervisor:

Targeted photodynamic therapy for bacterial infections photosensitizers, singlet oxygen, targeting molecules, MRSA, staphylococcus Supervisor:

Endodontal microbiology

Project titles:

Constant depth film fermentor models of endodontal infections Supervisor:

Molecular mechanisms of enterococcal resistance to root canal treatments and host defences Supervisor:

Injectable, antibacterial, remineralising materials for tooth and bone repair

Project titles

Self adhesive, re-mineralising, antibacterial dental restorative materials dental restoration,Ìý methacrylate, calcium phosphate, antibacterial release / action Supervisor: /

Replacement of PMMA bone cement with a modified dental composite polymethylmethacrylate (PMMA), bone cement, dental composite, strength, antibacterial Supervisor: /

Degradable composite bone cement development calcium phosphate, degradable polymers, bone cement, drug release ³§³Ü±è±ð°ù±¹¾±²õ´Ç°ù:Ìý

Mucosal immunity

Project titles:

Mucosal immune response in health and disease Innate, adaptive, immunity, inflammation, macrophage, Toll-like receptors

Transcriptomic analysis of oral inflammatory disease Transcriptomics, inflammation, human disease, next generation sequencing, bioinformatics

Understanding epithelial immunity to bacterial and viral infection Inflammation, toll-like receptors, inflammasome, autophagy, next generation sequencing

Understanding the mechanisms driving oral inflammation Innate immunity, inflammation, toll-like receptors, human disease, probiotics, dysbiosis

Studying the role of probiotics in the regulation of mucosal inflammation and immunity

Investigating how autophagy influences mucosal immune responses Innate immunity, toll-like receptors, Nod-like receptors, epithelial cells, macrophages

Ìý³§³Ü±è±ð°ù±¹¾±²õ´Ç°ù:

Ìý

Oral medicine

Project titles:

Development of patient-related outcomes (PRO) measures in oral mucosal diseases Supervisor:

Innate Immunity defects in oral mucosal disease Supervisor:

Efficacy of antibiotic prophylaxis in reducing the risk of jaw osteonecrosis in individuals exposed to bisphosphonates who undergo dental extractions Supervisor:

Mucosal immune response in health and disease Innate and adaptive immunity, inflammation, macrophage, Toll-like receptors Supervisor:

Transcriptomic analysis of oral inflammatory disease Transcriptomics, inflammation, human disease, next generation sequencing, bioinformatics Supervisor:

Understanding the mechanisms driving oral inflammation Innate immunity, inflammation, toll-like receptors, human disease, probiotics, dysbiosis Supervisor:

Studying the role of probiotics in the regulation of mucosal inflammation and immunity Supervisor:

Migraine and oral health: are the two diseases linked? Supervisor:

The oral microbiome and cancer Supervisor:

Defining the core outcome set in trigeminal neuralgia - the TRINCOS study Supervisor:

Oral health and performance

Project titles:

The natural history of the dental pellicle and its relationship to dental erosion in elite sport Oral health and performanceÌýin elite sportÌý Nasal, oral and gut microbiomes for elite sport performance and population health Oral biomarkers for monitoring elite athlete performance and health Physical activity, inflammation and periodontal health Supervisor:

Paediatric Dentistry

Project titles:

Investigations of the effectiveness of remineralising composites as a restorative material in children pain management,paediatric dentistry, sedation, anxiety management Supervisor:

Periodontal Microbiology

Project titles:

Constant depth film fermentor models of ginigivitis and periodontitis gingivitis, periodontitis, biofilms Supervisor:

Identification of natural antimicrobial agents for the treatment of periodontal disease periodontal pathogens, natural antimicrobials Supervisor:

The role of biofilms in infections of titanium surfaces periodontal pathogens, implants, titanium Supervisor:

Periodontitis and inflammatory bowel diseases: Exploring the nature of the association. Supervisor:

Periodontology

Project titles:

Treatment of Periodontitis and Cardiovascular Outcomes in Patients with Diabetes Supervisor:

Comparison of different modalities of periodontal therapy Supervisor:

Physical activity, inflammation and periodontal healthÌý Supervisor:

Mastication and periodontitis Supervisor:

Weight loss and periodontitis Supervisor:

Refined carbohydrate consumption and periodontal inflammation Supervisor:

Mechanisms of endothelial inflammation/damage in periodontitis Supervisor:

Periodontology and Dental Implantology

Project titles:

Characterisation of periosteum-derived grafts for periodontal repair/regeneration Supervisor:

Regulation of cementum development and repair Supervisor:

Development of a smart investigational product dispenser for clinical trials Supervisor:

Prosthodontics

Project titles:

The influence of implant-abutment corrosion products on cell metabolic pathways implant abutment, dental implants, corrosion, peri-implantitis, bone loss Supervisor: /

Microbiome

Modelling the effect of functional foods and their active components on oral microbiome Studying the impact of the microbiome on oral mucosal inflammatory disease Investigating ways to manipulate the oral microbiome Investigating the anti-inflammatory properties of probiotics in oral health and disease Supervisors: and

Nasal, oral and gut microbiomes for elite sport performance and population health.Ìý Supervisor:

Bacterial vitamin biosynthesis pathways and their role in the homeostasis of the oral microbiomeÌý Supervisor:

The oral microbiome and cancer Supervisor:

Ìý