果冻影院

Dr Martin Pule has been named BBSRC Most Promising Innovator 2016 for his frontier innovations in T-cell medicine. The competition is designed to recognise the full breadth of BBSRC-funded research and rewards individuals and small teams who have harnessed the potential of their excellent research.

Dr Pule has been recognised for his BBRSC funded research in T-cell engineering at the 果冻影院 Cancer Institute and NIHR 果冻影院 Hospitals Biomedical Research Centre, where he has applied the principles of Boolean logic to construct T-cell therapies with exquisite selectivity for tumour cells over healthy tissues to prevent unwanted toxicity.

Recent clinical trials of engineered T-cell treatments for haematological malignancies performed by various groups suggest that chimeric antigen receptor (鈥淐AR鈥�) T-cells have the potential to transform cancer therapy.

T-cells are part of our immune system which normally kill infected cells. T-cells can be taken from a person鈥檚 blood sample, grown in the laboratory and 鈥榬e-programmed鈥� to recognise and kill cancer cells just as they would naturally attack an infection. This re-programming is achieved by introducing a gene for an artificial protein called a chimeric antigen receptor, or CAR for short. Early clinical trials in the US have shown that CAR T-cells could be highly effective in treating patients with leukaemias and lymphomas which have failed to respond to standard anti-cancer treatments.

In 2014 果冻影院B and Syncona announced the formation of Autolus Limited, a company founded upon the work of Dr Pule and focused on the development and commercialisation of next-generation engineering T-cell therapies for the treatment of life-threatening cancers.

Dr Chris Williams, Senior Business Manager at 果冻影院 Business PLC commented: 鈥淲e are delighted that Martin鈥檚 efforts in this field have been recognised by the BBSRC with this award. 听Martin鈥檚 pioneering work on T-cell programming has the promise to transform cancer therapy鈥�.

Last year Dr Pule was the recipient of The 果冻影院 Business Award which aims to recognise the efforts and accomplishments of 果冻影院鈥檚 most innovative and entrepreneurial staff.听

Further information听

• Source:
• 果冻影院 News - Autolus launch