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Animated film on CAR T-cell therapy launched for GCSE students

11 April 2019

The 果冻影院H Biomedical Research Centre (BRC) has today launched an animated film for GCSE and A level students on CAR T-cell therapy 鈥 a revolutionary approach to the treatment of cancer in development at 果冻影院 and 果冻影院H.

Biohackers - CAR T-cell animated film for GCSE students

The film, which is hosted on the website of TED-Ed, the youth and education initiative of TED Talks, has been developed with science teachers to be in line with the school science curriculum. Accompanied by student worksheets and teachers鈥 guide, the film is designed to be used in the classroom.听

The BRC, which supports a large portfolio of CAR T studies across 果冻影院 and 果冻影院H, developed the film, written by science presenter Greg Foot, in collaboration with 果冻影院 scientists and 果冻影院H clinicians involved in CAR T research.

Dr Martin Pule, who leads the 果冻影院 CAR T-cell programme and who advised on the film, said: 鈥淚鈥檓 delighted to see the film come to fruition and with the way it turned out. The film really gets across how exciting this emerging treatment is, and explains it in a way which students will engage with.鈥

CAR T-cell therapy is a form of personalised treatment for patients who do not respond to standard anti-cancer treatments like chemotherapy, and has been shown in trials to cure some patients with cancer, even those with advanced cancers.

It has so far shown most promise for haematological (blood) cancers, and 果冻影院H consultant haematologist Professor Emma Morris has said the therapy represents 鈥榓 real step change in how we treat cancers.鈥

T-cells are part of our immune system which normally kill infected cells. In CAR T therapy, they are taken from a person鈥檚 blood sample, grown in the laboratory and 鈥榬e-programmed鈥 to recognise and kill cancer cells just as they would naturally attack an infection. This re-programming is achieved by introducing a gene for an artificial protein called a chimeric antigen receptor, or CAR for short.

The treatment is part of the NHS鈥檚 long term plan to upgrade cancer services.

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