果冻影院

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Wolfson Institute for Biomedical Research

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Dr Liam Browne

Neural circuits for pain听
Liam

Tel:听020 7679 6695
Email: liam.browne@ucl.ac.uk听
Lab Email Address:听brownelab@live.ucl.ac.uk
Website:
IRIS Profile:听听

Our goal is to understand how the brain processes pain. Pain is a protective system that alerts us to potential damage. When this alarm system goes wrong, pain can become highly debilitating and a disease in itself. Chronic pain is a global health issue affecting 1 in 5 people and treatments are inadequate, representing a huge unmet clinical need. We aim to provide a mechanistic understanding of the neural听听circuit computations that contribute to pain, and how they are altered in disease. This can inform targets for treatments for pain and provide core insights into the operation of the nervous system more broadly.听

We take a multidisciplinary approach at the interface between neuroscience, physiology, and engineering, using custom behavioural approaches, in vivo 2P microscopy, optogenetics, electrophysiology, and machine vision and machine learning. We have two areas of focus: (1) probing how pain is encoded and expressed by the cerebral cortex; (2) developing advanced tools for the study of behaviour, from reflexes to learning. These two areas of focus overlap allowing us to map the relationship between pain, emotion, motivation, learning and decision making in health and disease.

Academic Career

Academic Career

    • 2016 - present Wellcome Trust Sir Henry Dale Fellow - 果冻影院
    • 2015 - 2016 Marie Curie Fellow (return phase) - 果冻影院
    • 2013 - 2015 Marie Curie Fellow - Harvard Medical School and Boston Children's Hospital
    • 2009 - 2013 Postdoc with R. Alan North FRS - University of Manchester
      Publications

      Michoud, F., Seehus, C., Sch枚nle, P., Brun, N., Taub, D., Zhang, Z., . . . Lacour, S. P. (2021).听.听Nature Biotechnology. doi:10.1038/s41587-020-0673-2

      Schorscher-Petcu, A., Tak谩cs, F., & Browne, L. E. (2021).听.听eLife, 62026. doi:10.7554/eLife.62026

      Talbot, S., Doyle, B., Huang, J., Wang, J. -. C., Ahmadi, M., Roberson, D. P., . . . Woolf, C. J. (2020).听.听Journal of Allergy and Clinical Immunology. doi:10.1016/j.jaci.2020.01.003

      Atkinson, B., Chudasama, V., & Browne, L. (2019).听.听Methods in Molecular Biology. doi:10.1007/978-1-4939-9717-6_22

      Michoud, F., Sottas, L., Browne, L. E., Asboth, L., Latremoliere, A., Sakuma, M., . . . Lacour, S. P. (2018).听.听J Neural Eng, 15 (1), 015002-?. doi:10.1088/1741-2552/aa9126

      Browne, L. E., Latremoliere, A., Lehnert, B. P., Grantham, A., Ward, C., Alexandre, C., . . . Woolf, C. J. (2017).听.听Cell Rep, 20 (1), 89-98. doi:10.1016/j.celrep.2017.06.024

      Browne, L. E., & Woolf, C. J. (2014).听.听Nat Biotechnol, 32 (3), 240-241. doi:10.1038/nbt.2844

      Stelmashenko, O., Compan, V., Browne, L. E., & North, R. A. (2014).听.听Journal of Biological Chemistry, 289 (14), 9909-9917. doi:10.1074/jbc.m113.542811

      Browne, L. E., Nunes, J. P. M., Sim, J. A., Chudasama, V., Bragg, L., Caddick, S., & North, R. A. (2014).听.听Proc Natl Acad Sci U S A, 111 (1), 521-526. doi:10.1073/pnas.1318582111

      Browne, L. E., & North, R. A. (2013).听.听Journal of Neuroscience, 33 (37), 14801-14808. doi:10.1523/jneurosci.2022-13.2013

      Browne, L. E., Compan, V., Bragg, L., & North, R. A. (2013).听.听Journal of Neuroscience, 33 (8), 3557-3566. doi:10.1523/jneurosci.2235-12.2013

      Browne, L. E. (2012).听.听Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 1 (1), 56-69. doi:10.1002/wmts.24

      Browne, L. E., Cao, L., Broomhead, H. E., Bragg, L., Wilkinson, W. J., & North, R. A. (2011).听.听Nature Neuroscience, 14 (1), 17-18. doi:10.1038/nn.2705

      Bradley, H. J., Browne, L. E., Yang, W., & Jiang, L. (2011).听.听British Journal of Pharmacology, 164 (2b), 743-754. doi:10.1111/j.1476-5381.2011.01399.x

      Browne, L. E., Jiang, L. -. H., & North, R. A. (2010).听.听Trends in Pharmacological Sciences, 31 (5), 229-237. doi:10.1016/j.tips.2010.02.004

      Browne, L. E., Clare, J. J., & Wray, D. (2009).听.听Neuropharmacology, 56 (5), 905-914.

      Browne, L. E., Blaney, F. E., Yusaf, S. P., Clare, J. J., & Wray, D. (2009).听.听Journal of Biological Chemistry, 284 (16), 10523-10536. doi:10.1074/jbc.m807569200

      Group Members
      • Elisa Clemente (PhD student)
      • Jonathan Seaman (MSc student Neuroscience)
      • Denis Duagi (MSci Student Neuroscience)