果冻影院

The study, published by the聽Journal of the American College of Cardiology,聽found that for first-time marathon runners, training and completion of the marathon resulted in reductions in blood pressure and aortic stiffening in healthy participants that were equivalent to a four-year reduction in vascular age. The greatest benefits were seen in older, slower male marathon runners with higher baseline blood pressure.

Dr Charlotte Manisty (果冻影院 Institute of Cardiovascular Science &聽Barts Heart Centre)聽said: 鈥淎s clinicians are meeting with patients in the new year, making a goal-oriented exercise training recommendation鈥攕uch as signing up for a marathon or fun-run鈥攎ay be a good motivator for our patients to keep active. Our study highlights the importance of lifestyle modifications to slow the risks associated with aging, especially as it appears to never be too late as evidenced by our older, slower runners.鈥�

Arterial stiffening is a normal part of aging, but it also increases cardiovascular risk in otherwise healthy individuals by contributing to increased pulse pressure and ventricular overload, which are associated with dementia and cardiovascular and kidney diseases, even in the absence of plaque in the arteries. While blood pressure medication can modify arterial stiffness in established heart disease, more cardiovascular events occur in individuals without diagnosed high blood pressure.

Regular aerobic exercise is a lifestyle modification that has real-world implications, particularly with the growth in mass participation running as an increasingly popular form of non-prescribed exercise. The researchers used a group of 138 healthy, first-time marathon runners from the 2016 and 2017 London Marathon. They examined the participants before training and after marathon completion to determine if age-related aortic stiffening would be reversible with real-world exercise training.

Participants had no significant past medical or cardiac history and were not running for more than two hours per week at baseline. On average, participants were 37 years old and 49% were male. The researchers conducted all measurements before training started six months prior to the marathon and repeated them all within three weeks of completing the London Marathon, but no earlier than one week after the marathon to avoid any acute effects of exercise.

Assessments included blood pressure measurements and measurements of aortic stiffness by cardiovascular magnetic resonance imaging. Biological aortic age was determined from the relationship between the participant鈥檚 age and aortic stiffness at three levels of the aorta.

The average marathon running time was 5.4 hours for women and 4.5 hours for men. When compared to training data and marathon completion times from 27,000 runners, these times were found to be consistent with a training schedule of six to 13 miles per week.

Training decreased systolic and diastolic blood pressure by 4 and 3 mmHg, respectively. Overall, aortic stiffness reduced with training and was most pronounced in the distal aorta with increases in distensibility of 9%. This amounted to the equivalent of an almost four-year reduction in 鈥榓ortic age鈥�. Older patients had greater changes with exercise training, with males and those running slower marathon times deriving greatest benefit.

Dr Manisty added: 鈥淥ur study shows it is possible to reverse the consequences of aging on our blood vessels with real-world exercise in just six months. These benefits were observed in overall healthy individuals across a broad age range and their marathon times are suggestive of achievable exercise training in novice participants.鈥�

Although the study only recruited healthy participants, those with hypertension and stiffer arteries might be expected to have an even greater cardiovascular response to exercise training.

The Marathon Study was funded by the British Heart Foundation, Cardiac Risk in the Young, and the Barts Cardiovascular Biomedical Research Centre.

Links

• 果冻影院 Institute of Cardiovascular Science

Image

• 颁谤别诲颈迟听

Media contact

Rowan Walker

Tel: +44 (0)20 3108 8515

Email: rowan.walker [at] ucl.ac.uk