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Liver and Pancreaticobiliary Cancer
Spotlight on ECRs
Dr Pilar Acedo shares how she became co-head of the Pereira / Acedo Lab, where she focuses on early detection of pancreatic cancer and cholangiocarcinoma.
In this video interview, Dr Pilar Acedo highlights the value of working in a hospital at 果冻影院 to incorporate patients into her translational Repurposing TIN Pilot Data Fund project.
Our work听
Our mission at the Pereira/Acedo Group () is to lead the way in advancing the understanding and management of liver, pancreatic, and biliary diseases.
With a strong emphasis on clinical excellence and translational research, we are dedicated to unravelling the complexities of these challenging conditions, seeking minimally invasive early detection biomarkers, and developing novel therapeutic strategies to improve patient outcomes.
As a major education site, we are committed to nurturing the next generation of medical professionals, providing comprehensive training.
Collaborating with esteemed institutions globally, we aim to create a dynamic, multicultural research hub that fosters innovative solutions and translates scientific discoveries into tangible improvements in patient care.
Translational research
This research focuses on the discovery and validation of early detection biomarkers and the evaluation of novel therapeutic strategies to improve the outcome of patients with pancreaticobiliary diseases (e.g. cholangiocarcinoma and pancreatic cancer).
Our work includes:
- Biomarker discovery and validation for early diagnosis听
- Biomarkers as surrogate markers for treatment response听
- Serum, tissue and urine biobank collection听
- Nanoparticles as diagnostic tools and drug delivery systems
- 3D disease models (e.g. scaffolds, organoids)听
- Light-based and minimally-invasive therapies
- Imaging studies
- Spatial Transcriptomics
Clinical activities
A. Clinical trials听
Our clinical trials are based on testing Novel Therapies such as endoscopic ultrasound-guided radiofrequency ablation or irreversible electroporation (IRE).
B. Clinical Studies
In this study, doctors and researchers want to look at blood, urine and tissue samples from people who have symptoms similar to those with:
- pancreatic cancer
- neuroendocrine tumours (NETs) of the pancreas
- bile duct cancer听
In most cases, such symptoms are caused by many other benign conditions. But it is important to make sure that those that are due to cancer听are diagnosed early. We hope the results of this study will help them develop new tests to diagnose pancreatic cancer and NETs of the pancreas at an early stage.
The Pilar/Acedo Group听
Iulia Munteanu
Yang Yuchen
Syeda Hibba tul Hayee
Maria Rosado Rodr铆guez
Rosanne Roys
听
Current master's and visiting students
- Nurul Sarifah
- Samiihah Ollee
- Carolina San Pedro Liberal
- Elif Ceyda 脟elik
- Paula Gomez Mendez
- Eva Perez Barciela
- Andres Gordo Ortiz
- Maria Reviejo Diaz
Selected publications
- Beyer F, Rice S, Pereira S, et al. (2023) Health Technol Assess. 27 (7): 1-118.
- Papaefthymiou A, Johnson G, Pereira S et al. (2023) 听Cancers (Basels). 15(9):2627.听
- Nen茅 N, Ney A, Pereira S,听et al. (2023) . Nature. Communications Medicine. 3(10).
- Al-Akkad W, Acedo P, Ney A, Pereira S, et al. (2022) 听Cells. 11(22), 3652.
- Machicado J, Napoleon B, Pereira S, et al. (2022) Pancreatology. 22(7):994-1002.听
- Ney A, Garcia-Sampedro A, Acedo P, Pereira S,听et al. (2021) Front Oncol. 11:699401.听
- Marin J, Prete MG, Acedo P,听et al. (2021) 听Br J Cancer. 125(6):904.听
- Garcia-Sampedro A, Acedo P & Pereira S. (2021) Springer.
- Gonzalez-Valdivieso J, Garcia-Sampedro A, Pereira S, Acedo P,听et al. (2021)听听ACS Appl Mater Interfaces. 13(47): 55790-55805.
- Garcia-Sampedro A, Ney A, Mahamed I,听Acedo P,听et al. (2021) 听J Clin Med. 10(4):566.
- Skuja V, Nakov R, Acedo P, et al. (2020)听United European Gastroenterology Journal. 8(3); 355-358.
- Garcia-Sampedro A, Mahamed I, Acedo P, et al. (2020) 听Journal of Porphyrins and Phthalocyanines. 23(01);11-27
- Heinrich H, Rodriguez-lago I, Acedo P, et al. (2020)听听United European Gastroenterology Journal8(2);227-232.听
- Acedo P, Fernandes A & Zawacka-Pankau J. (2019)听听Future Science OA. 5(2).
- Enck P, Meisner S, Acedo P, et al. (2019) 听Sage Publications Inc. 7(6);859-863.
- Jiang L, Malik N, Acedo P, et al. (2019)听听Cell Death Discovery. 5;2058-7716.
Funding and partnerships听
Active Grants
- CRUK-PCUK-EPSRC project grants supporting multidisciplinary research to develop novel diagnostics and treatments for pancreatic cancer (projects: EDPAN; EXPAND; PaNanoMRI; EPIC DIVE).听
- EU Twinning and EPSRC grants to foster international collaborations and improve imaging of pancreatic cancer and precursor lesions.听
- PCUK Career Development (PI: ACEDO, project: BIOPANC) and PCRF (PI: Litchfield; co-PI: Pereira) grants supporting research on novel areas of the microbiome and immunobiology of pancreatic cancer to improve early pancreatic cancer detection. 听
- CRUK Early Detection and Diagnosis Programme Award. Project title: CANDETECT (Accelerating detection of upper gastrointestinal (UGI) cancers using a multi-cancer early detection platform in primary care).
Group Memberships
- EUPancreas (Integrated European Platform for Pancreatic Cancer Research)
- (IPSCSG) International PSC Study Group
- UK-PSC Consortium
- ENS-CCA
- CCA-UK
- UEG
Industry Collaborators
- Immunovia AB 鈥� Lund, Sweden
- Micronoma Inc 鈥� San Diego, USA
- Olink
- Nordic Biosciences
听
Related programmes
Contact details
- Dr Pilar Acedo (p.nunez@ucl.ac.uk)听(Twitter: )
- Prof. Stephen Pereira (stephen.pereira@ucl.ac.uk)
Address
Division of Medicine, Institute for Liver and Digestive Health 听
果冻影院 Medical School
Upper 3rd Floor Royal Free Hospital
LONDON
NW3 2QG