Immunosenescence and Ageing

The Centre for Immunosenescence and Ageing investigates mechanisms that control the differentiation and senescence / ageing of human T lymphocytes. We were among the first to identify human regulatory T cells and show that they are maintained by a high rate of proliferation in vivo.

Professor Arne Akbar has been made a British Society for Immunology Honorary Member in recognition of his outstanding contribution to immunology.

Prof. Akbar joins host Gordon Lithgow at The Buck Institute in California to break down the array of actors and pathways involved, including sestrins, immune memory, the gut microbiome, and more.

Is there such a thing as a normal immune system? Vivienne Parry investigates for BBC Radio 4, with the help of 果冻影院鈥檚 Arne Akbar.听

Our work

For the last 15 years, the Akbar Lab has focused on mechanisms of immune decline during ageing. We have identified a key role of p38 MAP kinase signalling in regulating both nutrient and senescence sensing pathways in human T cells.听

We also developed new technology for investigating immunity in human skin in vivo that have been adopted by other research groups in both academia and the biotech industry. Current collaborations using these methods include the University of Arizona, The Rockefeller University (New York) and the National University of Singapore.听

The interaction between clinicians and scientists leads to the translational aspects of our work. This has procured a 拢3.2M MRC Experimental Medicine Grant to investigate responses to recall antigen challenge in the skin of older humans after blocking p38MAP kinase.

Our experts

Mr Hugh Trahair

Terence Ma (PhD student)

(PhD student)

Collaborators

Janet Lord, University of Birmingham
Tao Dong, University of Oxford
Menna Clatworthy, University of Cambridge
David Mosser, University of Maryland

James Krueger, The Rockefeller University
Karolina Palucka, The Jackson Laboratory
Paul Macaray, National University of Singapore
Jonathan Crowston, National University of Singapore

Selected publications

Lanna A, Gomes DCO, Muller-Durovic B, et al. (2017).听 Nat Immunol. 2017;18(3):354-363.
Pereira BI, De Maeyer RPH, Covre LP, et al. (2020).听 2020;21(6):684-694.
Chambers ES, Vukmanovic-Stejic M, Shih BB, et al. (2021).听 Nat Aging. 2021;1(1):101-113.
Pearce听DRR,听Akarca听AUU,听De Maeyer听RPH,听搁别诲诲测听痴,听础办产补谤听础狈狈, et al. (2023) . Front. Oncol., Vol. 13.
Haston S,听Gonzalez-Gualda听E,听Morsli听S ...听Akbar, AN, et al.听(2023). . Cancer Cell, Vol. 41 (7), pp. 1242-1260.e6.

尝补辫丑补苍耻飞补迟听笔,听骋辞尘别蝉听顿颁翱,听础办产补谤听础狈听(2023). . Immunological Reviews, Vol听316 (1),听pp. 160-175.
Pallett听LJ,听Swadling听L,听Diniz听M,听Maini听AA ...听础办产补谤听础, et al.听(2023). . Nature 614, 334鈥�342.
Lanna听A,听Vaz听B,听D'Ambra听C,听Valvo听S ... 础办产补谤听础狈, et al.听(2022). . Nat Cell Biol, 24, 1461鈥�1474.
De Maeyer听RPH,听础办产补谤听础狈听(2022). . Nat Aging 2, 280鈥�281 (2022).
贵颈补谤诲听骋,听厂迟补惫谤颈苍颈诲别蝉听痴,听颁丑补尘产别谤蝉听贰厂,听贬别补惫别测听厂,听贵谤别别尘补苍听础,听叠补濒濒听搁,听础办产补谤听础狈听(2021). . Nat Rev Urol 18, 597鈥�610.

Funding and partnerships

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Media

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Contact Details听

Professor Arne Akbar听
a.akbar@ucl.ac.uk听

Postal Address:听
果冻影院听
Windeer Institute
43 Clevelan St听
London
W1T 4JF