果冻影院

Our current research interest is fibrogenesis with focus on Hepatic Stellate Cell behaviour in liver fibrosis and liver cancer cell biology with a specific focus on fibrotic stroma - cancer cell interaction.听Further interests include genetic polymorphism heterogeneity - cell behaviour in diseases such as Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis and cancer development.

The Team鈥檚 research remit covers both identifying/characterization of human organ specific Extracellular Matrix and cellular components of tissues, with a specific focus on cell behaviour in 2D and 3D cell culture systems for improvement of new target identification and drug development.听

Together with the ENETS oncology team of the Royal Free Hospital we are exploring mesenteric fibrosis in small intestinal neuroendocrine tumours:

• pathogenesis and potential therapeutic targets
• early biomarker detection in mesenteric fibrosis
• Deep Sequencing of gastroenteropancreatic neuroendocrine carcinoma.

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1. Maria In锚s Castanho Martins
2. Saiji Kathiresu Nageshwaran
3. Giulia Lupo

听

1. Al-Akkad W, Acedo P, Vilia MG ...听Hall AR ...听Luong TV, Whittaker SR, Pereira SP,听Vallier L, Pinzani M, Rombouts K, Mazza G (2022). . Cells. 2022 Nov 17;11(22):3652.

2. Thanapirom K, Caon E, Papatheodoridi M, Frenguelli L, Al-Akkad W, Zhenzhen Z, Vilia MG, Pinzani M, Mazza G, Rombouts K (2021). . Cancers (Basel). 2021 Sep 30;13(19):4936.

3. Laskaratos FM, Levi A, Schwach G, Pfragner R, Hall A, Xia D, von Stempel C ...听Luong TV, Toumpanakis C, Mandair D, Caplin M, Rombouts K (2021).听. Frontiers Oncology. 2021 Feb 24;11:629665. eCollection 2021.

4. Dat NQ, Thuy LTT, Hieu VN ...听Rombouts K, Dong MP, Hanh NV ...听Pinzani M, Kawada N (2021). . Hepatology. 2021 Jun;73(6):2527-2545.听Epub 2021 May 22. Erratum in: Hepatology. 2022 Dec;76(6):1902.

5. B枚ttcher K, Longato L, Marrone G, Mazza G, Ghemtio L, Hall A, Luong TV, Caruso S, Viollet B, Zucman-Rossi J, Pinzani M, Rombouts K (2021).听. Am J Physiol Gastrointest Liver Physiol. 2021 Apr 1;320(4):G543-G556.

6. Pavlovi膰 N, Calitz C, Thanapirom K, Mazza G, Rombouts K, Gerwins P, Heindryckx F (2020). . Elife. 2020 Oct 26;9:e55865.

7. Zanieri F, Levi A, Montefusco D ...听Luong TV听...听Mazza G, Argemi J, Bataller R, Cowart LA, Kester M, Pinzani M, Rombouts K (2020).听. Cells. 2020 May 16;9(5):1237.

8. Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K ...听Pinzani M, Kawada N. . Journal of Hepatology. 2020 Apr 17. pii: S0168-8278(20)30228-2.

9. Barcena-Varela M, Paish H, Alvarez L ...听Rombouts K, Oakley F, Mann J, et al (2020).听. Gut. 2020 Apr 23. pii: gutjnl-2019-320205.

10. Kostrzewski T, Maraver P, Ouro-Gnao L, Levi A, Snow S, Miedzik A, Rombouts K*, Hughes D* (2019). . Hepatology Communication. 2019 Nov 13;4(1):77-91.听eCollection 2020 Jan. (*Contributed equally)

11. Mazza G, Telese A, Al-Akkad W, Frenguelli L, Levi A ...听Hall AR, Godovac-Zimmermann J, Luong TV, De Coppi P, Pinzani M, Rombouts K听(2019).听. Cells. 2019 Dec 28;9(1). pii: E83.

12. Laskaratos FM, Mandair D, Hall A, Alexander S, von Stempel C, Bretherton J, Luong T, Watkins J, Ogunbiyi O, Rombouts K, Caplin M, Toumpanakis C听(2020). . Endocrine. 2020 Mar;67(3):718-726.

13. De Chiara F, Thomsen KL, Habtesion A ...听Hall A, Andreola F, Paish HL, Reed LH, Watson AA, Leslie J, Oakley F, Rombouts K, et al听(2020). . Hepatology. 2020 Mar;71(3):874-892.

14. Giuffrida P, Curti M, Al-Akkad W, Biel C, Crowley C, Frenguelli L, Telese A, Hall A ...听Pinzani M, Di Sabatino A, *Rombouts K, *Mazza G听(2019).听. Inflamm Bowel Dis. 2019 Oct 18;25(11):1740-1750.听(*Contributed equally.)

15. Marrone G, De Chiara F, B枚ttcher K, Levi A, Dhar D, Longato L, Mazza G, Zhang ZZ, Marrali M, Fern谩ndez-Iglesias A, Hall A, Luong TV, Viollet B, Pinzani M, Rombouts K (2018). . Hepatology. 2018 Sep;68(3):1140-1153.

16. B枚ttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong TV, Tsochatzis EA, Thorburn D, Pinzani M (2018).听. Hepatology. 2018 Jul;68(1):172-186.

17. Mazza G, Al-Akkad W, Telese A, Longato L, Urbani L, Robinson B, Hall A听...听Rombouts K, Pinzani M (2017). . Scientific Report. 2017 Jul 17;7(1):5534. PubMed PMID: 28717194

18. Carloni V, Lulli M, Madiai S, Mello T, Hall A, Luong TV, Pinzani M, *Rombouts K, *Galli A (2017).听. Gut. 2018 Feb;67(2):348-361.

19. Longato L, Andreola F, Davies SS, Roberts JL, Fusai G, Pinzani M, Moore K, Rombouts K (2017). . Free Radic Biol Med. 2017 Jan;102:162-173.

20. Jalan R, De Chiara F, Balasubramaniyan V, Andreola F, Khetan V, Malago M, Pinzani M, Mookerjee RP, Rombouts K (2016). . Journal of Hepatology. 2016 Apr;64(4):823-33.

Contact details

• Email: Prof. Krista Rombouts (k.rombouts@ucl.ac.uk)

Address

Division of Medicine, Institute for Liver and Digestive Health 听
果冻影院 Medical School
Upper 3rd Floor Royal Free Hospital
LONDON
NW3 2QG