果冻影院

The maintenance of the extraordinary neuronal cytoarchitecture relies on听the compartmentalization of gene expression. This allows the neurons to regulate gene expression locally and independently in distant cellular compartments, such as in axon terminals, and respond rapidly to local signals. The 3鈥檜ntranslated region (UTR) of mRNAs play a fundamental role in regulating many aspects of RNA metabolism including transcript stability, localization and translation. We recently showed () that听Tp53inp2, a bifunctional mRNA abundantly expressed and localized in sympathetic neuron axons, is not translated in neuronal cells.听罢辫53颈苍辫2听mRNA is implicated in NGF signaling and is essential for the neuronal survival, axonal growth, and target innervation. However, how this mRNA regulates NGF signaling remains unknown. The long 3鈥橴TR of听Tp53inp2听mRNA may play a role in this regulation. So, my goal is to understand the mechanisms by which听Tp53inp2听mRNA coordinates the regulation of NGF signaling and to identify the players that may be responsible for coordinating its bifunctional state.