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Stroke Research

Amyloid PET scans of iatrogenic cerebral amyloid angiopathy (CAA)
Susceptibility-weighted MRI of iatrogenic cerebral amyloid angiopathy (CAA)

Researching stroke prevention, treatment and management, and functional recovery after stroke.

Lead:

Stroke Research Centre team:

Jonathan Best

Schederazade Feerick (CRN Team)
Marilena Marinescu (CRN Team Lead)
Riham Muhammad (CRN Team)
Yee-Chin Lee (CRN Team)
Alex Lewis (CRN Team)
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Philip Nash
Sabaa Obarey (CRN Team)
Hatice Ozkan
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Georgia RaingoldÌý(CRN team)

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Research Goals

  • To understand the underlying mechanisms of cerebrovascular disease, with a focus on neuroimaging
  • To improve acute treatment and secondary prevention of stroke
  • To develop innovative treatments to prevent stroke, targeting both small and large artery diseases
  • To investigate how cerebral small vessel disease relates to intracerebral haemorrhage and vascular cognitive impairment
  • To conduct randomised controlled trials, investigating important questions relevant for clinical practice in stroke.

Funded Research Projects

  • Prevention of hypertensive injury to the brain by intensive treatment: Intracerebral Haemorrhage. Funded by a Stroke Association Priority Programme Grant for Intracerebral Haemorrhage
    Ìý
  • Cerebral amyloid angiopathy cohort to characterize the natural history and establish biomarkers relevant to prognosis
    Ìý
  • (Microbleeds International Collaborative Network)Ìý
  • (Prevention Of Hypertensive Injury to the Brain by Intensive Treatment after IntraCerebral Haemorrhage: a pilot randomized trial of home telemetry-guided treatment)
  • SIGNAL
    Ìý
  • OPTIMAS: OPtimal TIMing of Anticoagulation after AF-associated acute ischaemic Stroke: a randomised controlled trial
Recent publications from Stroke Research

2020

Mc Lernon S, Schwarz G, Wilson D, Ambler G, Goodwin R, Shakeshaft C, Cohen H, Yousry T, Salman RAS, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Terry L, Werring DJ
Association between critical care admission and 6-month functional outcome after spontaneous intracerebral haemorrhage
Journal of the Neurological Sciences 418:15 Nov 2020

Almarzouki A, Wilson D, Ambler G, Shakeshaft C, Cohen H, Yousry T, Salman RA-S, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Werring DJ
Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage.
Sci Rep 10(1):15529 23 Sep 2020

Best JG, Barbato C, Ambler G, Du H, Banerjee G, Wilson D, Shakeshaft C, Cohen H, Yousry TA, Salman RA-S, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Werring DJ, Clinical Relevance of Microbleeds in Stroke (CROMIS-2) collaborators
Association of enlarged perivascular spaces and anticoagulant-related intracranial hemorrhage.
Neurology 15 Sep 2020
DOI:

Lyndon D, Davagnanam I, Wilson D, Jichi F, Merwick A, Bolsover F, Jager HR, Cipolotti L, Wheeler-Kingshott C, Hughes D, Murphy E, Lachmann R, Werring DJ
MRI-visible perivascular spaces as an imaging biomarker in Fabry disease
Journal of Neurology 19 Oct 2020

Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, ....Houlden H, ….. Werring DJ, et al
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nature Genetics 16 Nov 2020

Perry RJ, Smith CJ, Roffe C, Simister RJ, Narayanamoorthi S, Marigold R, Willmot M, Dixit A, Hassan A, Quinn T, Ankolekar S, Zhang L, Banerjee S, Ahmed U, Padmanabhan N, Ferdinand P, McGrane F, Banaras A, Marks IH, Werring DJ
Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control study
Journal of Neurology, Neurosurgery and Psychiatry 05 Nov 2020

Ulivi L, Kanber B, Prados F, Davagnanam I, Merwick A, Chan E, Williams F, Hughes D, Murphy E, Lachmann RH, Wheeler-Kingshott CAMG, Cipolotti L, Werring DJ
White matter integrity correlates with cognition and disease severity in Fabry disease.
Brain 03 Nov 2020

Werring DJ
The STOP-AUST trial: a test for the spot sign in intracerebral haemorrhage
Lancet Neurol 28 Oct 2020

Hostettler IC, O'Callaghan B, Bugiardini E, O'Connor E, Vandrovcova J, Davagnanam I, Alg V, Bonner S, Walsh D, Bulters D, Kitchen N, Brown MM, Grieve J, Werring DJ, Houlden H, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators
ANGPTL6 genetic variants are an underlying cause of familial intracranial aneurysms.
Neurology 26 Oct 2020

Wardlaw JM, Doubal F, Brown R, Backhouse E, Woodhouse L, Bath P, Quinn TJ, Robinson T, Markus HS, McManus R, O’Brien JT, Werring DJ, Sprigg N, Parry-Jones A, Touyz RM, Williams S, Mah YH, Emsley H
Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol
European Stroke Journal 11 Oct 2020

Werring DJ, Al-Shahi Salman R
Untangling the natural history of cerebral arteriovenous malformations.
Journal of Neurology, Neurosurgery and Psychiatry 01 Oct 2020

Almarzouki A, Wilson D, Ambler G, Shakeshaft C, Cohen H, Yousry T, Salman RA-S, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Werring DJ
Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage.
Sci Rep 10(1):15529 23 Sep 2020

Du H, Pan X, Liu N, Chen J, Chen X, Werring DJ, Ambler G,...... Fujian Medical Team Support Wuhan for COVID-19
The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.
Respiratory Research 21(1):241 21 Sep 2020

Maskery MP, Holscher C, Jones SP, Price CI, Strain WD, Watkins CL, Werring DJ, Emsley HCA
Glucagon like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review.
J Cereb Blood Flow Metab 271678X20952011 20 Sep 2020

Yakushiji Y, Tanaka J, Wilson D, Charidimou A, Noguchi T, Kawashima M, Nishihara M, Best J, Ide T, Nagaishi Y, Mizoguchi M, Hara H, Werring DJ
Proportion of intracerebral haemorrhage due to cerebral amyloid angiopathy in the East and West: Comparison between single hospital centres in Japan and the United Kingdom
Journal of the Neurological Sciences 416:15 Sep 2020

Best JG, Barbato C, Ambler G, Du H, Banerjee G, Wilson D, Shakeshaft C, Cohen H, Yousry TA, Salman RA-S, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Werring DJ, Clinical Relevance of Microbleeds in Stroke (CROMIS-2) collaborators
Association of enlarged perivascular spaces and anticoagulant-related intracranial hemorrhage.
Neurology 15 Sep 2020

Knol MJ, Lu D, Traylor M, Adams HH, Rafael J Romero J, Smith AV, Fornage M, Hofer E, Liu J, Hostettler IC, Luciano M, …….Werring DJ, Schmidt H, Wardlaw JM, Ikram MA, Seshadri S, Launer LJ, Markus HS, Alzheimer’s Disease Neuroimaging Initiative
Association of common genetic variants with brain microbleeds: A Genome-wide Association Study.
Neurology 10 Sep 2020

Murphy SJ, Werring DJ
Stroke: causes and clinical features
Medicine 01 Sep 2020

George Ntaios, Patrik Michel, Georgios Georgiopoulos, Yutao Guo, Wencheng Li, Jing Xiong……
David J. Werring, Arvind Chandratheva, Laura Benjamin, Robert Simister, Richard Perry et al
Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry.
Stroke STROKEAHA120031208 Sep 2020

Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Cerebral venous thrombosis: a practical guide.
Pract Neurol 29 Aug 2020
10.1136/practneurol-2020-002415

Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, …. Werring DJ, Wilcock D, Wilson MR, Zlokovic BV, Verma A
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy.
Alzheimers Dement (Amst) 12(1):e12053 03 Aug 2020

Tsivgoulis G, Katsanos AH, Seiffge DJ, Paciaroni M, Wilson D, Koga M, Macha K, Cappellari M, Kallmünzer B, Polymeris AA, Toyoda K, Caso V, Werring DJ, Engelter ST, De Marchis GM, RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen, Verona registry collaborators
Fatal Intracranial Hemorrhage Occurring after Oral Anticoagulant Treatment Initiation for Secondary Stroke Prevention in Patients with Atrial Fibrillation
European Journal of Neurology 01 Aug 2020

Isabel C Hostettler, MD, Menelaos Pavlou, PhD, Gareth Ambler, PhD, Varinder S Alg, MD, Stephen Bonner, FFICM, Daniel C Walsh, FRCS, Diederik Bulters, FRCS, Neil Kitchen, PhD, Martin M Brown, FRCP, Joan Grieve, MD, Henry Houlden, PhD, David J Werring, PhD, FRCP on behalf of the Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators
Assessment of the Subarachnoid Hemorrhage International Trialists (SAHIT) Models for Dichotomized Long-Term Functional Outcome Prediction After Aneurysmal Subarachnoid Hemorrhage in a United Kingdom Multicenter Cohort Study.
Neurosurgery, Volume 87, Issue 6, December 2020, Pages 1269–1276

Belsten J, Werring DJ, Jones H, Heales S, Pope S
Cerebrospinal fluid folate, ascorbate, and tetrahydrobiopterin deficiency in superficial siderosis: A new potential mechanism of neurological dysfunction?
Journal of the Neurological Sciences 414:15 Jul 2020

Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, Wu O….Perry R…
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
The Lancet 396(10262):1574-1584 14 Nov 2020

Banerjee G, Chan E, Ambler G, Wilson D, Cipolotti L, Shakeshaft C, Cohen H, Yousry T, Al-Shahi Salman R, Lip GYH, Muir KW, Brown MM, Jäger HR, Werring DJ. Cognitive impairment before atrial fibrillation-related ischemic events: neuroimaging and prognostic associations. Journal of the American Heart Association 2020; 9(1):e014537 DOI:

Banerjee G, Werring DJ. Feasibility of clinical trial recruitment for cerebral amyloid angiopathy: A specialist single centre experience. J Neurol Sc 2020; 409:116580.DOI:

Banerjee G, Ambler G, Keshavan A, Paterson RW, Foiani MS, Toombs J, Heslegrave A, Dickson JC, Fraioli F, Groves AM, Lunn MP, Fox NC, Zetterberg H, Schott JM, Werring DJ. Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy. Journal of Alzheimer’s Disease, online 1st March 2020.DOI:

Banerjee G, Ambler G, Keshavan A, Paterson RW, Foiani MS, Toombs J, Heslegrave A, Dickson JC, Faioli F, Groves AM, Lunn MP, Fox NC, Zetterberg H, Schott NM, Werring DJ.Ìý Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy.Ìý Journal of Alzheimer’s Disease, online 21st April 2020

Banerjee G, Ambler G, Wilson D, Hostettler IC, Shakeshaft C, Lunawat S, Cohen H, Yousry T, Al-Shahi Salman R, Lip GYH, Houlden H, Muir KW, Brown MM, Jager HR, Werring DJ, CROMIS-2 collaborators.Ìý Baseline factors associated with early and late death in intracerebral haemorrhage survivors.Ìý European Journal of Neurology, online 29th March 2020

Banerjee G, Wilson D, Ambler G, Hostettler IC, Shakeshaft C, Cohen H, Yousry T, Al-Shahi Salman R, Lip GYH, Houlden H, Muir KW, Brown MM, Jager HR, Werring DJ, CROMIS-2 collaborators. Longer term stroke risk in intracerebral haemorrhage survivors.Ìý Journal of Neurology, Neurosurgery & Psychiatry, online 17th June 2020

Belsten J, Werring DJ, Jones H, Heales S, Pope S.Ìý Cerebrospinal fluid folate, ascorbate, and tetrahydrobiopterin deficiency in superficial siderosis:Ìý A new potential mechanism of neurological dysfunction?ÌýÌýJournal of the Neurological Sciences 414: 15th July 2020

Hostettler IC, Morton MJ, Ambler G, Kazmi N, Gaunt T, Wilson D, Shakeshaft C, Jäger HR, Cohen H, Yousry TA, Al-Shahi Salman R, Lip G, Brown MM, Muir K, Houlden H, Bulters DO, Galea I, Werring DJ, CROMIS-2 collaborators. Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage. Journal of Neurology, Neurosurgery and Psychiatry, online 10 January 2020.

Lim ST, Thijs V, Murphy SJX, Fernandez-Cadenas I, Montaner J, Offiah C, Marquardt L, Kelly PJ, Bath PM, Lim S-Y, Ford GA, Norrving B, Cox D, Prodan CI, Barber PA, Werring DJ, Perry R, Zgaga L, Dawson J, McCabe DJH.Ìý Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke:Ìý systematic review and meta-analysis.Ìý J Neurol, online 9th June 2020

Marrinan E, Chen L, Werring D, Turner D. Reducing delays to administration of prothrombin complex concentrate in patients with vitamin K antagonist-related intracerebral haemorrhage. British Journal of Hospital Medicine 2020;81(2):1-6.DOI:

Morton MJ, Hostettler IC, Kazmi N, Alg VS, Bonner S, Brown MM, Durnford A, Gaastra B, Garland P, Grieve J, Kitchen N, Walsh D, Zolnourian A, Houlden H, Gaunt TR, Bulters DO, Werring DJ, Galea I, Genetics and Observational Subarachnoid Haemorrhage Study investigators. Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage. Journal of Neurology, Neurosurgery and Psychiatry, online 1st March 2020.

Schlemm L, Endres M, Werring DJ, Nolte CH. Benefit of intravenous thrombolysis in acute ischemic stroke patients with high cerebral microbleed burden. Stroke 2020; 51(1):232-239
DOI:

Seiffge DJ, De Marchis GM, Kogg M, Paciaroni M, Wilson D, Cappellari M, Macha MD D, Tsivegoulis G, Ambler G, Arihiro S, Bonati LH, Bonetti B, Kallmünzer B, Muir KW, Bovi P, Gensicke H, Inoue M, Schwab S, Yaghi S, Brown MM, Lyrer P, Takagi M, Acciarrese M, Jäger HR, Polymeris AA, Toyoda K, Venti M,
Traenka C, Yamagami H, Alberti A, Yoshimura S, Caso V, Engelter ST, Werring DJ, RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen and Verona registry collaborators. Ischemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation. Annals of Neurology, online 27 February 2020.

Tsivgoulis G, Katsanos AH, Seiffge DJ, Paciaroni M, Wilson D, Koga M, Macha K, Cappellari M, Kallmunzer B, Polymeris AA, Toyoda K, Caso V, Werring DJ, Engelter ST, De Marchis GM, RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen, Verona registry collaborators.Ìý Fatal intracranial hemorrhage occurring after oral anticoagulant treatment initiation for secondary stroke prevention in patients with atrial fibrillation.ÌýÌýEuropean Journal of Neurology, online 25th April 2020

Wallace AC, Talelli P, Crook L, Austin D, Farrell R, Hoad D, O’Keeffe A, Marsden J, Fitzpatrick R, Greenwood R, Rothwell J, Werring D. Exploratory randomized double-blind placebo controlled trial of botulinum therapy on grasp release after stroke (PrOMBiS). Neurorehabilitation and Neural Repair, online 1st January 2020

Wardlaw J, Bath PMW, Doubal F, Heve A, Sprigg N, Woodhouse LJ, Blair G, Appleton J, Cvoro V, England T, Hassan A, Werring DJ, Montgomery A.Ìý Protocol:Ìý The Lacunar Intervention Trial 2 (LACI-2).Ìý A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease.Ìý European Stroke Journal, online 20th April 2020
Ìý
Werring DJ, Lynch DS.Ìý Monogenic small vessel diseases - rare but still important.Ìý Nature Reviews Neurology, 30th April 2020


2018

Al-Shahi Salman R, Dennis MS, Murray GD, Innes K, ….Werring DJ … Roffe J. The Restart or Stop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials 2018; 19-1.

Alg VS, Ke X, Grieve J, Bonner S, Walsh DC, Bulters D, Kitchen N, Houlden H, Werring DJ. Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis. British Journal of Neurosurgery, online 15 Jan 2018.

Banerjee G, Alvares D, Bowen J, Adams ME, Werring DJ. Minimally symptomatic cerebral amyloid angiopathy-related inflammation: three descriptive case reports. Journal of Neurology, Neurosurgery, and Psychiatry, online 13 March 2018.

Banerjee G, Wilson D, Ambler G, Osei-Bonsu Appiah K, Shakeshaft C, Lunawat S, Cohen H, Yousry T, Lip GYH, Muir KW, Brown MM, Al-Shahi Salman R, Jäger HR, Werring DJ, CROMIS-2 Collaborators. Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy. Stroke, online 1 January 2018.

Banerjee G, Summers M, Chan E, Wilson D, Charidimou a, Cipolotti L, Werring DJ. Domain-specific characterisation of early cognitive impairment following spontaneous intracerebral haemorrhage. Journal of the Neurological Sciences 2018; 391:25-30.
Goren N, Avery J, Dowrick T, Mackle E, Witkowska-Wrobel A, Werring D, Holder D. Multi-frequency electrical impedance tomography and neuroimaging data in stroke patients. Scientific Data 2018; 5:180112

Dineen RA, Pszczolkowski S, Flaherty K … Werring DJ …. Sprigg N. Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial. BMJ Open 2018; 8-2:e019930.

Hilkens NA, Van Asch CJJ, Werring DJ, Wilson D…Jäger HR … DIAGRAM study group. Predicting the presence of macrovascular causes in non-traumatic intracerebral haemorrhage: the DIAGRAM prediction score. Journal of Neurology, Neurosurgery and Psychiatry, 2018; 18.

Hunter E, Cliff M, Armstrong M, Manji H, Jager HR, Chiodini P, Brown M. Active neurocysticercosis at the Hospital for Tropical Diseases, London: a clinical case series. Transactions of the Royal Society of Tropical Medicine and Hygiene 2018; 112(7):326-334.

Kotecha D, Breithardt G, Camm AJ …. Werring D ….Kirchhof P. Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference. Europace, online 2 Jan 2018.

Lip GYH, Banerjee A, Boriani G, Chiang CE, Fargo R, Freedman B, Lane DA, Ruff CT, Turakhia M, Werring D et al. Antithrombotic therapy for atrial fibrillation: CHEST Guideline and Expert Panel Report. Chest, 2018 in press

MacGregor Sharp M, Bulters D, Brandner S, Holton J, Verma A, Werring DJ, Carare RO. The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy. Neuropathology and Applied Neurobiology, online 27 Feb 2018.

Phyu P, Merwick A, Davagnanam I, Bolsover F, Jichi F, Wheeler-Kingshott C, Golay X, Hughes D, Cipolotti L, Murphy E, Lachmann RH, Werring DJ. Increased resting cerebral blood flow in adult Fabry disease: MRI arterial spin labelling study. Neurology 2018; 90(16):e1379-1385.

Seiffge DJ, Kägi G, Michel P ….Werring D …NOACISP study group. Rivaroxaban plasma levels in acute ischemic stroke and intracerebral haemorrhage. Annals of Neurology, online 2 Feb 2018.

Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O’Brien J, Pantoni L, Pasquier F et al. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimer’s and Dementia 2018; 14-3:280-292.


Tsivgoulis G, Wilson D, Katsanos AH, Sargento-Freitas J, Marques-Matos C, Azevedo E, Adachi T, von der Brelie C, Aizawa Y, Abe H et al. Neuroimaging and clinical outcomes of oral anticoagulant associated ICH. Annals of Neurology, online 26th September 2018.

Werring DJ. Winston Churchill's cerebrovascular disease: small vessels with big implications. Journal of the Royal Society of Medicine 2018; 111(9): 314-315.

Werring DJ. CT scanning to diagnose CAA: Back to the future? The Lancet Neurology, online 10 January 2018.20

Wilson D, Ambler G, Shakeshaft C, Brown MM, Charidimou A, Al-Shahi Salman R, Lip GYH, Cohen H, Banerjee G, Houlden H et al. Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attach (CROMIS-2): a multicentre observational cohort study. Lancet Neurology 2018; 17(6): 539-547

Ziff OJ, Banerjee G, Ambler G, Werring DJ. Statins and the risk of intracerebral haemorrhage inpatients with stroke: systematic review and meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 2018 in press.

Ziff OJ, Werring DJ. Statins after intracranial haemorrhage: seizing a new opportunity? British Journal of Clinical Pharmacology, 2018 in press,

2017

Banerjee G, Wilson D, Ambler G, Osei-Bonsu Appiah K, Shakeshaft C, Lunawat S, Cohen H, Yousry T, Lip GYH, Muir KW, Brown MM, Al-Shahi Salman R, Jager HR, Werring DJ, CROMIS-2 Collaborators.Ìý .Ìý Stroke, online 15 December 2017. DOI:Ìý10.1161/STROKEAHA.117.019409

Banerjee G, Summers M, Chan E, Wilson D, Charidimou A, Cipolotti L, Werring DJ.Ìý Domain-specific characterisation of cognitive impairment following intracerebral haemorrhage.Ìý International Journal of Stroke, online 1 November 2017.

Banerjee G, Carare R, Cordonnier C, Greenberg SM, Schneider JA, Smith EE, Buchem MV, Grond JV, Berbeek MM, Werring DJ.Ìý Ìý Journal of Neurology, Neurosurgery and Psychiatry 2017; 88(11): 982-994.Ìý DOI:Ìý10.1136/jnnp-2016-3146974

Banerjee G, Kim HJ, Fox Z, Jaeger HR, Wilson D, Charidimou A, Na HK, Na DL, Seo SW, Werring DJ. Brain 2017; 140:1107-1116 doi: 10.1093/brain/awx003.

Charidimou A, Imaizumi T, Moulin S, Biffi A, Samarasekera N, Yakushiji Y, Peeters A, Vandermeeren Y, Laloux P, Baron J-C et al. Neurology, 2017 Aug 22;89(8):820-829. doi: 10.1212/WNL.0000000000004259. Epub 2017 Jul 26.

Charimidou A, Turc G, Oppenheim C, Yan S, Scheitz JF, Erdur H, Klinger-Gratz PP, El-Koussy M, Takahashi W, Moriya Y et al. . Stroke, published online 18th July 2017 doi: 10.1161/STROKEAHA.116.012992. [Epub ahead of print]

Croall ID, Lohner V, Moynihan B, Khan U, Hassan A, O-Brien JT, Morris RG, Tozer DJ, Cambridge VC, Harkness K. Clinical Science 2017; 131(2):1361-1373 doi: 10.1042/CS20170146. Print 2017 Jun 1.

Hostettler Moreno I, Alg V, Shabi N, Jichi F, Bonner S, Walsh D, Bulters D, Kitchen N, Brown M, Houlden H et al. . Neurosurgery 2017 Jul 25. doi: 10.1093/neuros/nyx365. [Epub ahead of print]

Jakel L, Van Nostrand WE, Nicoll JAR, Werring DJ, Verbeek MM.Ìý .Ìý Clin Sci (Lond) 2017; 131(19):2469-2488.Ìý DOI:Ìý10.1042/CS20170033

Jang YK, Kim HJ, Lee JS, Kim YJ, Kim KW, Kim Y, Jang H, Lee J, Lee JM, Kim S-J et al.Ìý Ìý Scientific Reports 22 November 2017; 7(1):15984.Ìý DOI:Ìý10.1038/s41598-017-16298-1

Koohi N, Vickers DA, Lakshmanan R, Chandrashekar H, Werring DJ, Warren JD, Bamiou D-E. . Journal of the American Academy of Audiology 2017; 28(6):491-505 10.doi: 10.3766/jaaa.15139.

Koohi N, Vickers D, Warren J, Werring D, Bamiou DE. . BMJ Open 2017; 7(4)

Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, VICCCS group et al.Ìý ÌýÌý Alzheimers Dement, online 19 October 2017.Ìý DOI:ÌýÌý

Skrobot OA, Love s, Kehoe PG, O’Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, ford GA, Kalaria RN et al. . Alzheimer’s and Dementia 2017; 13(6):624-633 doi: 10.1016/j.jalz.2016.10.007. Epub 2016 Dec

Turner D, Scully M, Stone S, Werring DJ. . Practical Neurology 2017 Oct;17(5):380-382. doi: 10.1136/practneurol-2016-001581. Epub 2017 Jun 3.

Wilson D, Seiffge DJ, Traenka C, Basir G, Purrucker JC, Rizos T, Sobowale OA, Sallinen H, Yeh S-J, Wu TY et al. Neurology 2017; 88(18):1693-1700 doi: 10.1212/WNL.0000000000003886. Epub 2017 Apr 5.

Wilson D, Chatterjee F, Farmer SF, Rudge P, McCarron MO, Cowley P, Werring DJ. Annals of Neurology 2017; 81(3):333-343 doi: 10.1002/ana.24850. Epub 2017 Jan 28.

Wilson D, Hostettler IC, Ambler G, Banerjee G, Jager HR, Werring DJ. Journal of Neurology 2017; 264(4):664-673 doi: 10.1007/s00415-017-8398-y. Epub 2017 Feb 2.

Yakushiji Y, Charidimou A, Noguchi T, Nishihara M, Eriguchi M, Nanri Y, Kawaguchi A, Hirotsu T, Werring DJ, Hara H.Ìý Ìý Internal Medicine, online 16 October 2017.Ìý DOI:ÌýÌý10.2169/internalmedicine.8393-16

2016

Chan E, Altendorff S, Healy C, Werring DJ, Cipolotti L. J Neurol Sci. 2017 Feb 15;373:100-104.doi: 10.1016/j.jns.2016.12.028. Epub 2016 Dec 19.

Charidimou A, Schmitt A, Wilson D, Yakushiji Y, Gregoire SM, Fox Z, Jäger HR, Werring DJ. J Neurol Sci. 2017 Jan 15;372:178-183.doi: 10.1016/j.jns.2016.11.021. Epub 2016 Nov 12.Ìý

Jiad E, Gill SK, Krutikov M, Turner D, Parkinson MH, Curtis C, Werring DJ. . Pract Neurol. 2017 Jan;17(1):28-34. doi: 10.1136/practneurol-2016-001469. Epub 2017 Jan 3.

Kongbunkiat K, Wilson D, Kasemsap N, Tiamkao S, Jichi F, Palumbo V, Hill MD, Buchan AM, Jung S, Mattle HP, Henninger N, Werring DJ. Neurology. 2017 Feb 14;88(7):638-645. doi: 10.1212/WNL.0000000000003605. Epub 2017 Jan 27.

Koohi N, Vickers D, Chandrashekar H, Tsang B, Werring D, Bamiou DE2. Disabil Rehabil. 2017 Mar;39(6):586-593. doi: 10.3109/09638288.2016.1152608. Epub 2016 Mar 23.

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