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The Division of Neuropathology at Queen Square is a leading academic and diagnostic neuropathology department in the UK. The department provides services for the National Hospital of Neurology and Neurosurgery, 果冻影院 Hospital, and receives a substantial number of national referrals.
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Neuropathology & neurotoxicity of prion diseases
Prof. Sebastian Brandner, in collaboration with Department of Neurodegenerative Disease听and听
The principal focus of the MRC Prion Unit is on the human prion disease, and the research strategy is aimed at both rapid developments to target these areas of public health concern and a long term approach to the understanding of prion disease and the wider relevance of prion-like molecular mechanisms in pathobiology
Neuropathology of epilepsy
Dr Maria Thom is affiliated with the Department of Clinical and Experimental Epilepsy
In the recent years we have focused studies on specific pathologies including hippocampal sclerosis. In our post mortem series we have, using stereological analysis, examined the distribution of cell loss along the longitudinal axis, noting variability of the pattern in relation to patients seizures. We have been examining the differences in patterns of interneuronal loss in the hippocampus in relation to seizures. We have published studies on the severity of Alzheimer-type pathology in a large post-mortem series of patients with epilepsy and correlated accelerated aging with evidence of old traumatic brain injury incurred as a result of seizures. We are also studying the contribution of immature and progenitor cells types, including doublecortin, NG2 and nestin-positive neurones in the pathology focal cortical dysplasia (FCD). We have recently explored the mechanisms of altered patterns of myelination observed in FCD. We have studied the immunophenotype and molecular-genetic characteristics of subtypes of long-term epilepsy-associated tumours (LEATs). In sudden and unexpected death in epilepsy (SUDEP) we have been identifying the distribution of acute neuronal injury through neuronal expression of HIF1 alpha and VEGF.