果冻影院

Professor Hardy is Chair of the Molecular Biology of Neurological Disease at 果冻影院 Queen Square Institute of Neurology and a member of the UK Dementia Research Institute at 果冻影院. He is an international figure in the research of neurodegenerative disease and is globally recognised for his contribution to developing breakthrough therapies for dementia. He created the amyloid cascade hypothesis of Alzheimer鈥檚 disease - the major theory of the disease. His聽groundbreaking studies on the genetics underlying Alzheimer鈥檚 has brought us closer to understanding the root causes of the disease, forming the foundations for many promising therapies currently in development.聽He was elected a Fellow of the Royal Society in 2009, won the聽Breakthrough Prize in Life Sciences in 2016,聽and shared the聽prestigious Brain prize in 2018.

鈥淚t is a great honour of course to get the knighthood and I鈥檓 of course very proud of the work we did working with families with Alzheimer鈥檚 disease collected by my Institute of Neurology colleague Dr Martin Rossor. I think we now know much more about what causes Alzheimer鈥檚 disease. But we also have to acknowledge that our work has not yet led to much better treatments. Hopefully the next period of clinical and basic research will start to make that important breakthrough.鈥� Professor John Hardy

Professor Hardy聽has collaborated widely and, together with his co-workers, has deposited whole genome association data for Parkinson鈥檚 disease, Alzheimer鈥檚 disease, motor neurone disease, Bipolar disease and controls in an open access format allowing direct interrogation by the scientific community. Together with Gerald Higgins, Hardy聽published the amyloid cascade hypothesis in the early nineties, which is still the major theory on how Alzheimer鈥檚 disease arises, placing amyloid beta at the centre of early harmful changes in the brain. The amyloid-targeting drug aducanumab was approved earlier this year for Alzheimer's in a聽landmark decision by the FDA in the US.

鈥淥n behalf of the entire UK DRI community we warmly congratulate John on his knighthood. John is not only a mainstay of the neurodegeneration research community, contributing many seminal discoveries and insights over the years, but also a phenomenal leader and a terrific friend who cares for all those around him. We are delighted that his many contributions are being recognised鈥攁 richly deserved honour indeed鈥攁nd look forward to seeing him in a suit.鈥澛燯K DRI Directors聽Professor Bart De Strooper聽and聽Dr Adrian Ivinson.

鈥� I am delighted to congratulate my Queen Square Institute of Neurology colleague Professor John Hardy on his Knighthood. This is truly wonderful news and recognition of John鈥檚 major contribution to understanding the genetics of Alzheimer鈥檚 聽disease thereby paving the way for potential treatments. John鈥檚 research is a powerful example of how interdisciplinary collaboration linking clinical colleagues studying families, geneticists and molecular neuroscientists has led to a deep understanding of the genetic mechanisms of Alzheimer鈥檚 diseases. John鈥檚 knighthood is great recognition of decades of focussed research and am sure I speak for all Institute colleagues in very warmly congratulating him 鈥� Professor Michael Hanna, Director, 果冻影院 Queen Square Institute of Neurology

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