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Nature magazine article, press release and FAQs
Findings of our latest study were published in an article in Nature Microbiology magazine on 5th September 2024.听The article and its听accompanying press release can be viewed or downloaded below.
This builds on our previous study published in Nature magazine in 2019, which can be viewed or听downloaded below, with press release and FAQs document.
We would like to thank participating families for their time and contributions to Baby Biome Study and to recognise the research midwives and other research staff for their hard work.
Resources - 2024
Picture left: Key bacterium - credit: Dave Goulding/Wellcome Sanger Institute
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Resources - 2019
Project Summary听
We aim to understand how interactions between microorganisms, the immune system, and clinical, social, and behavioural factors during pregnancy and early life influence later health and disease. We hypothesise that the nascent immune system interacts with the first microbiota colonisers, driving immune-mediated disease when the colonisation process is disturbed.听This work includes exploring the impact of elective caesarean section, and of antibiotics given in pregnancy or labour, on the development of microbiota in a child's gastrointestinal tract.
Baby Biome Study is a proposed large-scale UK birth cohort study and biobank, with longitudinal follow-up through electronic health data linkage to undertake ground-breaking research in this field.
Funded by the Wellcome Trust, we have already completed a large pilot to Baby Biome Study, which has recruited nearly 3,500 mother-baby pairs at birth. Participants have been recruited from maternity units at Barking, Havering and Redbridge University Hospitals NHS Trust, University Hospitals of Leicester NHS Trust, and 果冻影院 Hospitals NHS hospital trusts. We are now seeking funding to expand this study to around 40,000 participants.
Publications
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Presentations
- Brocklehurst. The microbiome in late pregnancy and mother to child transmission. BASHH Conference 2016. Oxford.
- Yan Shao, Samuel C. Forster, Evi Tsaliki, Angela Strang, Nandi Simpson, Nitin Kumar, Mark Stares, Alison Rodger, Nigel Field, Trevor D. Lawley. Stunted gut microbiota assembly and increased pathogen colonisation are associated with caesarean section: findings from the Baby Biome Study birth cohort. British Maternal and Fetal Medicine Society. Edinburgh, UK 2019.
New Birth Cohort Study
Visit the Children Growing Up in Liverpool (CGULL) webpage:听
Prof Nigel Field to co-lead new Wellcome 鈥�4M - Microbes, Milk, Mental Health and Me鈥� study - Read more on 果冻影院 News
听Follow up study: RHIO
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