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Early Phase Cancer Clinical Trials Programme

We deliver novel, cutting-edge therapies through early phase clinical trials across a wide range of Cancers, aiming to improve patient outcomes and progress the development of impactful treatments.Ìý

The team comprises of a group of leading clinicians across medical oncology and haematology that are highly skilled in running complex Phase I/II clinical trials.Ìý These Principal Investigators are supported by Clinical Fellows, Research Nurses, Trial co-ordinators, data managers, laboratory scientists and pharmacists to deliver a robust and diverse portfolio of trials.Ìý

The team benefits from full integration with ¹û¶³Ó°ÔºH, a world class research hospital, providing expertise in Imaging,Ìý Pathology and Molecular Diagnostics as well as a wide array of different clinical specialities.

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Our Aims

To be a world-class early phase clinical trials programme, conducting high quality trials investigating novel cancer therapies.

Set-up, maintain and manage clinical trials through a trial life-cycle to ensure patients have a stream of available trials and treatment options.

Innovate and develop new clinical trials in collaboration with academic and industry partners.

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How We Operate

¹û¶³Ó°ÔºH/¹û¶³Ó°ÔºÌýis both a Cancer Research UK Centre and an Experimental Cancer Medicine Centre providing key infrastructure for cancer research. The ¹û¶³Ó°ÔºH/¹û¶³Ó°Ôº partnership has been awarded Comprehensive Biomedical Research Centre status by the National Institute for Health Research and Cancer is a major theme.

NIHR ¹û¶³Ó°ÔºH Clinical Research Facility

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The CRF is also supported by funding from Cancer Research UK and the ECMC. It has a remit to progress high quality clinical research in any domain but with a specific focus on early-phase clinical trials and experimental medicine.Ìý

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Our Expertise

Over the past two years we have recruited over 280Ìýpatients* across a diverse portfolio running approximately 94Ìýopen to recruitment clinical trials* across a variety of drug categories and cancer tumour groups.

* January 2019 – January 2022

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Our early phase cancer trials programme has a diverse portfolio of trials focused across on a wide range of different tumour categories.

Over the year we have showcased an expansive portfolio of cancer clinical trials across the following tumour groups:

Visit theÌýEarly Phase Cancer Trials Portfolio page to view our full Portfolio and current 'Open to Recruitment' clinical trials.

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Our Funders

We are funded by the National Institute for Health Research (NIHR), alongside grants from CRUK and theÌýECMC.

NIHR Biomedical research centre (BRC)

is a partnership between ¹û¶³Ó°Ôº Hospitals NHS Foundation TrustÌý(¹û¶³Ó°ÔºH) and ¹û¶³Ó°Ôº (¹û¶³Ó°Ôº). The ¹û¶³Ó°ÔºH BRC was established in 2007 as one of five centres that were competitively awarded funding by theÌýÌý(NIHR) to support world leading clinical translational research. In September 2016, the ¹û¶³Ó°ÔºH BRC was awarded £114M for 2017-2022 to enable continued growth in our experimental medicine and early translational research programmes.

Cancer is a key theme of the NIHR ¹û¶³Ó°ÔºHÌýBiomedical Research Centre and supports the infrastructure of the NIHR ¹û¶³Ó°ÔºH Clinical Research Facility (CRF).ÌýThe NIHR ¹û¶³Ó°ÔºH Clinical Research Facility (CRF) is a purpose-built environment dedicated to experimental medicine and clinical research. More information regarding the ¹û¶³Ó°ÔºH CRF can be found on the Our Structure page.

More information on the ¹û¶³Ó°ÔºH BRC can be found on their website link -Ìý

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Cancer research uk (CRUK)

CRUK is a leading UK registered charity responsible for leading and funding research in all aspects of cancer. Alongside funding the cancer theme of the NIHR ¹û¶³Ó°ÔºH Clinical Research Facility, they also fund the Cancer Research UK ¹û¶³Ó°Ôº Centre.

Information about CRUK can be found on their website at .

The Cancer Research UK ¹û¶³Ó°Ôº Centre (CRUK ¹û¶³Ó°Ôº Centre) is part of a national network of 13 research centres funded by Cancer Research UK dedicated to delivering world-leading cancer research, improved care for cancer patients and greater local engagement. More details can be found on theÌýCRUK ¹û¶³Ó°Ôº Centre website.

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Experimental cancer medicine centre (ECMC)

The Experimental Cancer Medicine Centre (ECMC) Network is a unique UK-wide initiative jointly funded by Cancer Research UK and the Health Departments of England, Wales, Scotland and Northern Ireland. Providing £70 million of infrastructure support, the Network of 18 centres brings together world-leading scientists and clinicians to drive the discovery, development and testing of new anti-cancer treatments for patients.

Further details on the network can be found on the .

The Centre supports a dedicated Clinical Research Facility (CRF) based at ¹û¶³Ó°ÔºH where a team of devoted medical staff including oncologists, research nurses and trial coordinators work together on a large portfolio of clinical trials, offering patients access to the latest new drugs. More details can be found on the ECMC at the ¹û¶³Ó°Ôº Cancer Institute website.

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