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New paper from B盲hler lab shows that yeast breathes to supply amino acids for rapid growth
9 September 2020
Yeast cells normally grow using fermentation to generate energy, rather than respiration (similar to proliferating cancer cells). The authors show that fission yeast also needs respiration for fermentative growth to supply amino acids that are required for rapid proliferation.
Mitochondrial respiration is required for rapid fermentative proliferation of fission yeast cells by supplying amino鈥恆cid derivatives of the Krebs鈥恈ycle metabolite alpha鈥恔etoglutarate.
- Inhibition of the respiratory chain reduces growth and intracellular amino鈥恆cid concentrations, most notably arginine.
- Arginine supplementation, and its catabolism into amino acids that are normally derived from alpha鈥恔etoglutarate, are sufficient to restore rapid growth.
- Inhibition of the respiratory chain also triggers a gene鈥恊xpression response through TOR inhibition, and the regulated proteins show biased amino鈥恆cid compositions reflecting their shortage in this condition.
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