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Developing a partnership to inform UK-Brazil TB control. Investigating the efficacy of BCG vaccination following latent tuberculosis treatment
Project Summary
The overall aim of this collaboration is to develop a partnership that would bring together two major programmes of work in epidemiology in the UK and immunology in Brazil to inform the development of a major trial that would assess whether the efficacy of BCG vaccination in individuals with latent TB infection (LTBI) is improved by treating pre-existing latent infection.
The project includes a literature review, mathematical modelling and a pilot randomised controlled trial in Brazil on the efficacy of BCG following treatment of latent TB infection.